On August 23-24, the 10th National Undergraduate Basic Medical Innovation Research and Experimental Design Forum took place at Sun Yat-sen University in Guangzhou. The event was jointly organized by the Basic Medical Group of the National Demonstration Center for Experimental Education in Higher Education Institutions and the Collaborative Education Working Group for Basic Medical Innovation and Entrepreneurship. Central South University sent 11 teams to the competition, and they excelled, standing out from 878 finalist projects. The teams brought home 7 Gold Awards, 3 Silver Awards, and 1 Bronze Award. In addition, they won the Best Academic Award, Best Team Award, and Best Style Award. Central South University was also honored with the “Excellent Organization Award” and the “Outstanding Contribution Unit for Innovative Talent Cultivation” for its achievements over the past nine sessions. Professor Qin Xiaoqun from the School of Basic Medical Sciences was recognized with the “Excellence Contribution Award”. This year, the university made a significant breakthrough by winning its first Gold Award in a non-basic clinical track.

Awards Summary

• Gold Award (Basic Clinical Track):Research on the Role and Mechanism of ATF3/NINJ1-mediated Alveolar Epithelial Cell Pan-apoptosis in Acute Lung Injury

  Team Leader:Tu Xinyu

  Members:Wang Kunbo, Xiao Yunying, Ou Yetong, Xie Yanxin

  Supervisors:Li Ming, Zhong Wenjing

  Special Award:Best Style Award

• Gold Award (Basic Clinical Track):Mechanism of PKMYT1 Inducing Cisplatin Resistance in Osteosarcoma by Promoting TCOF1 Phosphorylation

  Team Leader:Zhuang Yan

  Members:Jiang Yingting, Zhang Yibo, Hu Hongkun, Tang Jinxin

  Supervisors:Tu Chao, Li Zhihong

• Gold Award (Interdisciplinary Track):Hydrogel Sustained Release System Loaded with BAZ to Inhibit NLRP3 Inflammasome Activation for Periodontitis Improvement

  Team Leader:Tan Junyuan

  Members:Yang Wangwang, Chen Yimeng, Jiang Yike, Zhu Hongjin

  Supervisors:Li Wenjie, Yu Jingang

  Special Award:Best Academic Award

• Gold Award (“Belt and Road” Track):DNMT1-induced ARG1+ Macrophage Senescence to Inhibit Nerve Regeneration in Traumatic Spinal Cord Injury

  Team Leader:Hou Yingshan

  Members:Yang Luning, Xie Guangyang, Lin Yuzhe, Lai Jieyu

  Supervisors:Li Yusheng, Cao Yong

• Gold Award (Dentistry Track):Regulation of OSCC Immune Evasion by KIR2DS4-mediated NK Cell Cytophagy

  Team Leader:Luo Liuya

  Members:Li Jin, Yang Xin, Chen Zhuonan, Huang Xiaolu

  Supervisors:Yan Fei, Zhou Yueying

• Gold Award (Preventive Medicine Track):Construction of an Electrochemical Deposition Metal-Organic Framework Nanoprobe for Pyocyanin Detection in Pseudomonas aeruginosa

  Team Leader:Peng Zongqi

  Members:Yan Haifu, Liu Qian, Li Zhengfei, Su Fanzhen

  Supervisors:Ding Ping, Kai Tianhan

• Gold Award (Preventive Medicine Track):Combined Use of RPA-CRISPR and Lanthanide Metal-Organic Framework Materials for mcyE Detection

  Team Leader:Yang Yang

  Members:Cheng Qi, Dao Lucheng, Guo Huijie, Li Zhongxu

  Supervisors:Wu Pian, Ding Ping

  Special Award:Best Team Award

• Silver Award (Basic Clinical Track):KCNK1 Upregulation of H3K18 Lactylation through LDHA Promoting Malignant Progression of Breast Cancer

  Team Leader:Ma Wanyun

  Members:Xiang Jinwei, Jiao Jie, Kong Xinyu, An Zhihan

  Supervisors:Wang Fuyan, Huang Xiaoting

• Silver Award (Traditional Chinese Medicine Track):Inhalable Quercetin-Tobramycin Co-Amorphous Particles against Pseudomonas aeruginosa Biofilm

  Team Leader:Liu Yan

  Members:Chen Yuyan, Fan Junping, Hu Yunshu, Qiao Menglin

  Supervisors:Liu Wenjie

• Silver Award (Traditional Chinese Medicine Track):Genipin Nanomedicine Targeting Pancreatic β-Cell Mitochondria for T2DM Treatment

  Team Leader:Feng Can

  Members:Xu Zilu, Liang Xiyuan, Lu Xinyao, Lei Ruoyan

  Supervisors:Huang Qiong, Ai Kelong

• Bronze Award (Dentistry Track):Regulation of Immune Barrier Formation by OSCC Tumor Cells through SPP1/CD44

  Team Leader:Fang Xinyuan

  Members:Shao Chuhan, Cao Dan, Zhou Zhirui

  Supervisors:Liu Ousheng, Bin Xin

This competition has been ongoing since November 2023, with the Innovation and Entrepreneurship Office and Xiangya School of Medicine providing strong support and attention. The School of Basic Medical Sciences took the lead, collaborating with the Xiangya School of Public Health, Xiangya School of Stomatology, Xiangya School of Pharmacy, and three affiliated hospitals to meticulously plan and organize the event. After multiple rounds of university-level competitions, selection contests, regional heats, and extensive training, 11 teams emerged as national finalists. With the dedicated guidance and support of their mentors and judges, the students rigorously refined their projects, showcasing their strong theoretical knowledge, outstanding innovation, and excellent teamwork to achieve impressive results in the finals.

This forum is a significant event for displaying and exchanging the innovative research and experimental design skills of undergraduate students in basic medicine across the country. It plays a vital role in nurturing high-caliber, innovative talents with strong practical skills and creative thinking. Throughout the competition, many undergraduates with exceptional innovative abilities stood out, fully reflecting the university's spirit of unity and progress and its solid achievements in talent cultivation.

(First Review: Yu Ting, Second Review: Li Ruijun, Third Review: Zeng Yi)